- Merck’s COVID-19 pill, also known as Molnupiravir, reduced hospitalization and death by 50%.
- 7.3% of patients who received Molnupiravir were hospitalized or died within 29 days, compared with 14.1% of patients who received the placebo.
- If approved by the U.S. Food and Drug Administration, Molnupiravir would be the first oral medication for COVID-19.
Pharmaceutical giant Merck last week said its COVID-19 pill was shown to hospitalization and death by approximately 50%. The pill, known as Molnupiravir, could be the first oral antiviral medication for COVID-19.
“RNA is the genetic material used by the coronavirus as the blueprint for buildings its proteins,” Perlman tells Verywell. “When Molnupiravir is introduced into the coronavirus RNA, it causes a massive number of errors in the genetic material thereby blocking the ability to build proteins and replicate.”
The study results, based on a trial with 775 patients, showed that 7.3% of COVID-19 patients who received Molnupiravir were hospitalized or died within 29 days, compared with 14.1% who received the placebo. There were no reported deaths among those who received the pill, while eight deaths were recorded in patients who received the placebo.
All patients were required to have at least one risk factor for poor disease outcome, such as obesity, diabetes, and heart disease.
Is Molnupiravir Safe?
While the results seem promising, Perlman notes that the treatment was tested in relatively small trials. There’s also no long-term data on the drug’s safety yet.
“It is not an alternative to vaccines,” Perlman says. “At best, the treatment is expected to reduce the risk of deterioration by half, and only when given early in the course of illness.”
In addition, compared to the vaccines, Molnupiravir is expected to have a heftier price tag. “The treatment is more costly, reportedly $700 per course, and supply is expected to be limited,” Perlman says.
Kristen Nichols, PharmD, an infectious disease pharmacist based in Ohio, also says that the results from the study cannot be considered definitive until the full study is published and peer-reviewed.
She adds that vaccination is a form of primary prevention that trains the immune system to respond to the virus, while the COVID-19 pill would serve as disease management after diagnosis. For immunocompromised patients who may not respond to vaccination, she says, Molnupiravir could be a good alternative.
“We still desperately need to vaccinate as many Americans as possible, and as many people across the globe,” Nichols says.
Next Step: FDA Authorization
According to Merck, the company plans to submit an application for emergency use authorization to the Food and Drug Administration. White House Chief Medical Advisor Anthony Fauci said that the FDA will review Merck’s data as quickly as possible.
If authorized, Merck expects to produce courses of treatment by the end of the year.